Progressive Supranuclear Palsy

A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)

Also Known As:

Steele Richardson Olszewski Syndrome; Progressive Supranuclear Ophthalmoplegia; Supranuclear Palsy, Progressive; Palsy, Progressive Supranuclear; Richardson's Syndrome; Steele-Richardson-Olszewski Disease; Supranuclear Palsy, Progressive, 1; Progressive Supranuclear Palsies; Richardson Syndrome; Steele Richardson Olszewski Disease; Supranuclear Ophthalmoplegia, Progressive; Supranuclear Palsies, Progressive; Ophthalmoplegia, Progressive Supranuclear; Progressive Supranuclear Palsy 1; Steele-Richardson-Olszewski Syndrome

Nervous System Diseases: 14178
- Neurodegenerative Diseases: 42472
  - Tauopathies: 2793
    - Progressive Supranuclear Palsy: 1232
- Neurologic Manifestations: 7102
  - Paralysis: 14164
    - Ophthalmoplegia: 867
      - Progressive Supranuclear Palsy: 1232
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Basal Ganglia Diseases: 346
      - Progressive Supranuclear Palsy: 1232
  - Movement Disorders: 4634
    - Progressive Supranuclear Palsy: 1232
- Cranial Nerve Diseases: 554
  - Ocular Motility Disorders: 514
    - Ophthalmoplegia: 867
      - Progressive Supranuclear Palsy: 1232
Eye Diseases: 3522
- Ocular Motility Disorders: 514
  - Ophthalmoplegia: 867
    - Progressive Supranuclear Palsy: 1232
Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Neurologic Manifestations: 7102
    - Paralysis: 14164
      - Ophthalmoplegia: 867
        Progressive Supranuclear Palsy: 1232

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Drug/Important Bio-Agent (IBA)